Antiinflammatorisch
- Bani S, Kaul A, Khan B, Ahmad SF, Suri KA, Gupta BD, et al. Suppression of T lymphocyte activity by lupeol isolated from Crataeva religiosa. Phytother Res 2006; 20: 279-87.
- Reyes CP, Nunez MJ, Jimenez IA, Busserolles J, Alcaraz MJ, Bazzocchi IL. Activity of lupine triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2. Bioorg Med Chem. 2006 Mar 1;14(5):1573-9. Epub 2005 Dec 5.
- Banno N, Akihisa T, Tokuda H, Yasukawa K, Higashihara H, Ukiya M, et al. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci Biotechnol Biochem 2004; 68: 85-90.
- Zdzisinska B, Rzeski W, Paduch R, Szuster-Ciesielska A, Kaczor J, Wejksza K, et al. Differential effect of betulin and betulinic acid on cytokine production in human whole blood cell cultures. Pol J Pharmacol 2003; 55: 235-8.
- Vasconcelos, JF, Teixeira, MM, Barbosa-Filho, J.M., et al.: The triterpenoid lupeol attenuates allergic airway inflammation in a mirine model. Intern Immunopharm 2008: 8: 1216-21
- Ikeda, Y, Murakami A, et al.: Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36. J Immunol 2007 ; 178(8): 4854-64.
- Altinier, G.: Characterization of topical antiinflammatory compounds in Rosmarinus officinalis L. J Agric Food Chem 2007. 55(5): 1718-23.
- Vasconcelos MA, Royo VA, Ferreira DS, Crotti AE, Andrade e Silva ML, Carvalho JC, et al. In vivo analgesic and anti-inflammatory activities of ursolic acid and oleanoic acid from Miconia albicans (Melastomataceae). Z Naturforsch [C] 2006; 61: 477-82.
Wundheilungsfördernd
- Harish BG, Krishna, V, Santosh Kumar, HS,et.al.: Wound healing activity and docking of glycogen-synthase-kinase-3?-protein with isolated triterpenoid lupeol in rats. Phytomed 2008; 15:763-67.
- Lim, S.W.: Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha. J Dermatol, 2007. 34(9): 625-34.
- Moura-Letts, G.: In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa. J Nat Prod, 2006. 69(6): 978-9.
- Galgon T, Wohlrab, W., Dräger, B., et al. Betulinic acid induces apoptosis in skin cancer cells and differentiation in normal human keratinocytes. Exp Dermatol 2005; 14: 1-9.
Antibakterielle und fungizide Wirkung
- Horiuchi, K.: Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE). Biol Pharm Bull, 2007. 30(6): 1147-9.
- Kuiate, J.R.: Antidermatophytic triterpenoids from Syzygium jambos (L.) Alston (Myrtaceae). Phytother Res, 2007. 21(2): 149-52.
- Gu JQ, Wang Y, Franzblau SG, Montenegro G, Yang D, Timmermann BN. Antitubercular constituents of Valeriana laxiflora. Planta Med 2004; 70: 509-14.
- Suksamrarn S, Panseeta P, Kunchanawatta S, Distaporn T, Ruktasing S, Suksamrarn A. Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana. Chem Pharm Bull (Tokyo) 2006; 54: 535-7.
Antivirale Wirkung
- Aiken C, Chen CH. Betulinic acid derivatives as HIV-1 antivirals. Trends Mol Med 2005; 11: 31-6.
- Yogeeswari P, Sriram D. Betulinic acid and its derivatives: a review on their biological properties. Curr Med Chem 2005; 12: 657-66.
- Pavlova NI, Savinova OV, Nikolaeva SN, Boreko EI, Flekhter OB. Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses. Fitoterapia 2003; 74: 489-92.
Hepatoprotektive Wirkung
- Abdel-Zaher, A.O.: Role of nitric oxide and reduced glutathione in the protective effects of aminoguanidine, gadolinium chloride and oleanolic acid against acetaminophen-induced hepatic and renal damage. Toxicology, 2007. 234(1-2): 124-34.
- Prasad, S.: Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice. Mol Nutr Food Res, 2007. 51(3): 352-9.
- Oh SH, Choi JE, Lim SC. Protection of betulin against cadmium-induced apoptosis in hepatoma cells. Toxicology 2006; 220: 1-12.
- Szuster-Ciesielska A, Kandefer-Szerszen M. Protective effects of betulin and betulinic acid against ethanol-induced cytotoxicity in HepG2 cells. Pharmacol Rep 2005; 57: 588-95.
- Kim KA, Lee JS, Park HJ, Kim JW, Kim CJ, Shim IS, et al. Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes. Life Sci 2004; 74: 2769-79.
Antitumorigene und antiproliferative Wirkung
- Braga, F.: Oleanolic acid inhibits the activity of the multidrug resistance protein ABCC1 (MRP1) but not of the ABCB1 (P-glycoprotein): Possible use in cancer chemotherapy. Cancer Lett, 2006.
- Rzeski W, Stepulak A, Szymanski M, Sifringer M, Kaczor J, Wejksza K, et al. Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells. Naunyn Schmiedebergs Arch Pharmacol 2006; 374: 11-20.
- Juan ME, Wenzel U, Ruiz-Gutierrez V, Daniel H, Planas JM. Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells. J Nutr 2006; 136: 2553-7.
- Eiznhamer DA, Xu ZQ. Betulinic acid: a promising anticancer candidate. IDrugs 2004; 7: 359-73.
- Lee, T.K.: Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model. Cancer Res, 2007. 67(18): 8800-9.
- Chintharlapalli, S.: Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res, 2007. 67(6): 2816-23.
- Kessler JH, Mullauer FB, de Roo GM, Medema JP. Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. Cancer Lett 2006.
- Kasperczyk, H.: Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene, 2005. 24(46): 6945-56.
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